Cd6 cd166
WebNov 15, 2014 · The two main known mammalian CD6 ligands, CD166/ALCAM and the very recently reported CD318, are widely expressed by both immune cells and a wide range of other cell types, including various epithelial and mesenchymal cell types, as well as many neoplasms. Moreover, CD6 is also a receptor for several pathogen- and damage … WebCD8受體（英語： CD8-receptor ）是细胞毒性T细胞的膜上標記（surface marker）之一。 當病菌入侵人體，有一部分必定會被廣佈的抗原呈現細胞（此時主要指非B細胞的巨噬細胞及棘狀細胞）給吞噬，其餘病菌則順利潛入正常的體細胞中。 病菌無論是進入正常體細胞或抗原呈現細胞，其構成抗原的部分必會 ...
Cd6 cd166
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CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene. It is also called CD166 (cluster of differentiation 166), MEMD, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat. Some literature sources have also cited it as the CD6 ligand (CD6L). It is expr… WebCD6 has two ligands, CD166 (ALCAM) and CD318. It plays an important role in the stabilization and maturation of immunological synapses by interacting with ALCAM. …
WebCD166 is an immunoglobulin superfamily cell adhesion molecule that is broadly expressed on developing and adult hematopoietic (e.g., activated T and B cells, monocytes, and dendritic cells) and non-hematopoietic (e.g., neural, endothelial, and epithelial) tissues. WebAug 4, 2015 · CD6 monoclonal antibodies differ in epitope, kinetics and mechanism of action. Characterization of CD6 mAbs provides an insight into how their functional effects …
WebCD6 has been exploited as a drug target as its expression is restricted, primarily to T cells, it has a well characterised cell surface ligand, CD166 and regulates T cell activation through a long cytoplasmic tail. CD6 can affect both the initiation and maintenance of T … WebCD6 is a receptor for CD166/ALCAM (activated leukocyte cell adhesion molecule) and for CD318 (CDCP1, CUB-domain-containing protein 1). Both of these molecules are strongly expressed by the majority of cancer cells. Both CD166 and CD318 are engaged in CD6-dependent adhesion of T lymphocytes. Some of the cell surface CD318 is shed from the …
WebOct 24, 2024 · Blockade of the CD6/CD166/CD318 axis prevents mammalian target of rapamycin activation and T cell proliferation but promotes oxidative stress and aerobic glycolysis. In addition, it …
WebWhile the nature of the CD5 ligand is still controversial, CD6 binds CD166/ALCAM, a cell adhesion molecule involved in progression and dissemination of epithelial cancers, including PCa. The purpose of the present study was to determine the role of CD5, CD6, and CD166/ALCAM gene variants in PCa. six and baggy little nightmaresWebSep 7, 2024 · Based on these and other findings, Saifullah et al. (2004) concluded that 3A11 and CD166 are distinct CD6 ligands. Using mass spectroscopy, proteomics, and immunoblot analysis, Enyindah-Asonye et al. (2024) determined that monoclonal antibody 3A11 recognized CD318 (CDCP1; 611735 ). Pull-down analysis confirmed that soluble CD6 … six and eight thousandWebThe 3A6 monoclonal antibody specifically binds to the activated leukocyte cell adhesion molecule (ALCAM), a 100-105 kDa transmembrane glycoprotein, also known as the CD6 ligand, CD166. It is composed of an immunoglobulin-like extracellular domain, a transmembrane region and a short cytoplasmic tail. six and cypressWebGeneral description. CD166 antigen (UniProt: Q13740; also known as Activated leukocyte cell adhesion molecule, CD166) is encoded by the ALCAM (also known as MEMD) gene (Gene ID: 214) in human. CD166 is a cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6 and homotypic cell-cell contacts. six and eightWebCD166, also known as ALCAM, located on the human chromosome 3q13.1-q13.2, is one of the ligands of the lymphocyte antigen CD6 and is also one of the members of the … six and eighty-three thousandthsWebAug 4, 2015 · CD6 monoclonal antibodies differ in epitope, kinetics and mechanism of action. Characterization of CD6 mAbs provides an insight into how their functional effects in vivo may be interpreted and their therapeutic use optimized, and revealed that itolizumab has a lower affinity compared with other CD6 domain 1 mAbs. six and eight went on a dateWebMay 1, 2024 · CD6 is a lymphocyte receptor selectively expressed on most T cells and some B cells. • CD6 is involved in cell-to-cell contacts and modulation of adaptive immune responses. • CD6 interacting partners include CD166/ALCAM, CD318 and certain PAMPS and DAMPS. • CD6 is implicated in the pathogenesis of a variety of immune-mediated … six and five hundredths