WebFeb 18, 2024 · PAH: Inhibits phosphodiesterase type 5 (PDE-5) in smooth muscle of pulmonary vasculature where PDE-5 is responsible for the degradation of cyclic guanosine monophosphate (cGMP). Increased cGMP concentration results in pulmonary vasculature relaxation; vasodilation in the pulmonary bed and the systemic circulation (to a lesser … WebJun 18, 2024 · Tablets and oral liquid medicine. Pulmonary arterial hypertension (PAH) is a condition where there is too high a blood pressure in the arteries which supply blood to your lungs from your heart. The arteries become narrowed so your heart has to work harder to pump blood to your lungs. Sildenafil relaxes the muscles in the walls of the arteries ...
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