Cisplatin magnesium wasting
WebWe documented inappropriate renal magnesium wasting in four patients. Two patients required hospitalization for symptomatic hypomagnesemia. We conclude that cisplatin … WebAfter filtration, approximately 10% to 20% of reabsorption occurs in the proximal tubule through paracellular pathways and driven by electrochemical gradients favoring magnesium movement out of the latter parts of the proximal tubule., Next, 50% to 70% of magnesium is reabsorbed in the thick ascending limb of the loop of Henle (TAL; Figure 2 ), …
Cisplatin magnesium wasting
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WebMay 19, 2024 · Aminoglycosides: Can cause renal magnesium wasting and subsequent deficiency . Antibiotics: ... Cisplatin-based chemotherapy: May cause hypomagnesemia . Dasatinib: May increase blood levels of … WebSep 1, 1986 · Cisplatin (cis-diamminedichloroplatinum II), a chemotherapeutic agent used against epithelial neoplasms, is known to cause hypomagnesemia and renal magnesium wasting. In order to further characterize the effect of multiple doses of this drug upon serum magnesium levels and renal magnesium handling, we prospectively studied 28 patients …
WebMagnesium plays an important role in the maintenance of intracellular K. An unrecognized and untreated Mg depletion can lead to a refractory K repletion. We describe two … WebCisplatin is a chemotherapy drug used to treat some forms of cancer. Note: ... Severe magnesium deficiency caused by cisplatin therapy has been reported to result in …
WebAug 16, 2024 · A single-region retrospective study from central Texas at Baylor Scott & White Cancer Clinics who were treated with two or more cycles of cisplatin were included. Standard hydration for this study was defined as normal saline before and after cisplatin along with potassium chloride 10 mEq and magnesium sulfate 1 g added to the … WebSep 9, 2024 · 17q12 deletion syndrome encompasses a broad constellation of clinical phenotypes, including renal magnesium wasting, maturity-onset diabetes of the young (MODY), renal cysts, genitourinary malformations, and neuropsychiatric illness. Manifestations outside of the renal, endocrine, and nervous systems have not been well …
WebJan 11, 2024 · Cisplatin commonly causes magnesium and potassium wasting, and electrolytes should be replaced as appropriate. The administration of 1 g magnesium intravenously with cisplatin might help to reduce ...
WebJan 12, 2024 · Hypomagnesemia is often associated with hypokalemia (due to urinary potassium wasting) and hypocalcemia (due both to lower parathyroid hormone secretion … mexican talavera dishesWebOct 1, 2024 · Cisplatin injury to renal tubules often impacts magnesium reabsorption, resulting in renal magnesium wasting and hypomagnesemia . Earlier studies suggest that cisplatin induces hypomagnesemia in 40–90% of patients receiving the treatment, and magnesium loss in turn aggravates cisplatin nephrotoxicity ( 3 , 5 ). how to buy maternity clothingWebMay 24, 2006 · Magnesium wasting in the proximal tubule and thick ascending limb should result in a fractional excretion greater than 10%. Metabolic alkalosis and hypokalemia may also have a role in magnesium excretion. Treatment of GS requires correction of the serum electrolyte abnormalities [ 2 ]. mexican tableware dishesWebCisplatin (cis-diamminedichloroplatinum II), a chemotherapeutic agent used against epithelial neoplasms, is known to cause hypomagnesemia and renal magnesium … how to buy matic on coinbaseWebAug 6, 2014 · Magnesium wasting is commonly seen in the course of cisplatin-induced AKI ; thus routine assessment of serum magnesium levels may be recommended in all patients receiving cisplatin treatment. Magnesium should be replaced adequately according to serum magnesium levels [ 22 ]. mexican tablecloth floralWebNational Center for Biotechnology Information mexican talavera light switch coversWebFeb 1, 1999 · Since the magnesium reabsorption process still remains to be fully characterized, the effect by cisplatin on this process remains uncertain. … how to buy maxwell technologies stock