Hif bnip3

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August undefined, 2024

Web缺氧诱导因子（HIF-1）的结构、调节与靶基因研究进展.pdf 2015-07-17 上传缺氧诱导因子（HIF-1）的结构、调节与靶基因研究进展,缺氧诱导因子,缺氧诱导因子1α,低氧诱导因子,轴向诱导因子,凋亡诱导因子,cns靶向因子修复体系,转录因子靶基因预测,影响因子,sci影响因子查询 Webbnip3的表达受到转录因子hif-1a的调控，在低氧诱导细胞自噬凋亡过程中起重要的作用。然而，唾液腺腺样囊性癌中BNIP3的表达、其调节的低氧诱导自噬通路及临床病理学行为国内外尚未有文献报道。

The role of hypoxia inducible factor 1 (HIF-1) in …

Web15 de out. de 2024 · Bellot, G. et al. Hypoxia-induced autophagy is mediated through HIF-induction of BNIP3 and BNIP3L via their BH3 domains. Mol. Cell Biol. 29, 2570–2581 (2009). Webhif-1蛋白水平的高低决定于细胞所处环境的氧含量。生理状态下，hif-1α蛋白水平极低[4]。但在低氧状态下，由于羟化过程受到抑制，hif-1α无法降解，hif-1α快速积累于胞质内，通过募集其他相关辅助蛋白形成复合体后，hif-1α最终转入细胞核，与靶基因dna ... sia home and away

Baicalin relieves hypoxia-aroused H9c2 cell apoptosis by …

WebBackground: To explore the roles of HIF1α- and HIF2α-regulated BNIP3 in hypoxia-induced injury of neurons. Methods: The sera of neonates with hypoxic-ischemic encephalopathy … Web27 de jul. de 2024 · (Bnip3) was substantially upregulated in the inner retinal layer after retinal I/R. In this regard, we further examined Bnip3 depletion in retinal neurons in vitro and in vivo and found the similar neuroprotective effects. Our results support the notion that the HIF-1α/BNIP3 pathway may have a critical role in inner retinal neurodegenera- Web8 de jan. de 2024 · Alterations in expression of BNIP3 and NIX mitophagy receptors induce stabilization of HIF-1a, a phenomenon that induces the socalled Warburg effect.An example of this phenomenon is depletion... siahn producer

IJMS Free Full-Text The Duration of Oxygen and Glucose …

WebNational Center for Biotechnology Information Web17 de mai. de 2024 · BNIP3 depletion halted mitophagy and enforced a PHD2-mediated downregulation of HIF-1α and its glycolytic program both in vitro and in vivo. … siah networkWeb1 de mai. de 2024 · However, the addition of exogenous disodium-fumarate (Fig EV4E) failed to rescue the levels of HIF-1α in the BNIP3-silenced cells. Together, these data … sia homeware

"Web目前认为低氧是通过hif－1诱导的非典型性唯bh3域蛋白 bcl－2/e1b 19 kda交互蛋白 3[bnip3/bnip3l(nix)]和mtor而介导细胞发生自吞噬作用的。这些线粒体相关BNIP蛋白能介导线粒体自吞噬(mitophagy)，而线粒体自吞噬反应能控制活性氧族(reactive oxygen species，ROS)的产生和DNA受损的代谢，从而使细胞产生适应性存活 ... " - Hif bnip3

Hif bnip3

Autophagy regulates hypoxia-induced osteoclastogenesis through …

Web15 de set. de 2001 · Bcl2/adenovirus EIB 19kD-interacting protein 3 (BNIP3) ... HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in … Web1 de set. de 2001 · To additionally check the role of Hif-1α in BNIP3 induction, CHO KA13 and C4.5 cells were subjected to normoxia or hypoxia for 16 h before being analyzed …

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Web21 de mar. de 2024 · BNIP3 (BCL2 Interacting Protein 3) is a Protein Coding gene. Diseases associated with BNIP3 include Hereditary Leiomyomatosis And Renal Cell … Web15 de jun. de 2024 · Unlike HIF-1α and REDD1 (expressed transiently), Bnip3 was time-dependently induced by iron chelation, and high levels of Bnip3 were detectable after 24-h treatment with CPX or Dp44mT (Fig. S4A, B).

WebBNIP3 is an atypical BH3-only protein that is known to cause mitochondrial dysfunction and cell death, but in parallel has also a role in protecting against cell death by inducing mitophagy. The mechanism for this process, however, remains poorly understood. Web1 de set. de 2024 · HIF-1α-BNIP3 signaling pathway contributes to mitophagosome formation in renal tubular cells in confocal assay. Representative immunofluorescence …

WebResults: The expression levels of BNIP3, HIF-1α and marker genes of autophagy were upregulated in ARPE-19 cells in response to hypoxia. Importantly, hypoxia-induced … Web27 de dez. de 2024 · HIF-1 α exerts its antiapoptotic function through transcriptional activation of antiapoptotic proteins: Bcl-2, apoptosis inhibitor (IAP-2), and GLUT1. On the other hand, a functional pathway of HIF-1 α can activate proapoptotic proteins: p53, Bax, and BNIP3 [ 5 ].

Web27 de jul. de 2024 · (Bnip3) was substantially upregulated in the inner retinal layer after retinal I/R. In this regard, we further examined Bnip3 depletion in retinal neurons in vitro …

WebAnti-HIF-1 alpha antibody [EP1215Y] (ab51608) View more associated products. Overview. Product name. HIF1a + BNIP3 Hypoxia Response Human Flow Cytometry Kit. Detection method. ... BNIP3 readout. … the pearline houseWebNational Center for Biotechnology Information the pearl indian restaurant audenshawWeb2 de set. de 2024 · 3.3. HIF-1α/BNIP3 Pathway Was Activated during Luteolysis. Previous studies have revealed that hypoxia is involved in the apoptosis of luteal cells in vitro [], implying that HIF-1α may participate in apoptosis during luteal regression in vivo.Thus, we detected the expression changes of HIF-1α signaling and then found an obvious … sia home office log inWebIn contrast, adenovirus-mediated BNIP3 overexpression significantly reversed the decreased mitophagy, and prevented enhanced kidney damage in tubular HIF-1α … the pearling industry slaveryWeb摘要：目的探讨乙酸钠(NaAc)对氧糖剥夺(OGD)损伤后皮质神经元的作用及低氧诱导因子-1α(HIF-1α)表达的影响。方法将OGD处理的皮质神经元作为脑缺血模型，采用细胞存活实验(CCK-8)、乳酸脱氢酶(LDH)释放实验检测NaAc处理后的神经元存活情况，Western blot方法检测OGD损伤后、NaAc处理后神经元中HIF-1α蛋白 ... sia home furnishingsWebWhile hypoxia-inducible factor (HIF) is a major actor in the cell survival response to hypoxia, HIF also is associated with cell death. Several studies implicate the HIF-induced putative … sia holdingWeb13 de jul. de 2024 · Hypoxia-inducible factor-1 (HIF-1) dependent expressions of DRP1 and phosphorylated DRP1 and mitophagy-related protein BNIP3 were significantly upregulated in hypoxia-surviving HCC cells (Fig. 1e). sia home sofa