High dose thiotepa

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Web22 de set. de 2024 · 30 to 60 mg by intravesical instillation into the bladder once; for maximum effect, the solution should be retained for 2 hours; if the patient cannot retain … WebThe incidence of neurotoxicity related to the combination of WBRT and high dose methotrexate is significantly higher in patients aged older than 60 years; withholding WBRT in the primary setting in these patients may be considered. Consider reducing or omitting cytarabine and thiotepa doses in older patients and/or those with co-morbidities.

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WebProspective studies of intensive chemotherapy regimens containing high-dose methotrexate, followed by hematopoietic stem cell transplantation have shown the most favorable outcomes, especially for patients receiving thiotepa-based … Web20 de out. de 2024 · Very few prospective studies have been conducted in this patient group. This study was a multicenter phase 1/2 study that investigated thiotepa in combination with ifosfamide, etoposide, and rituximab (TIER) for the treatment of PCNSL relapsed or refractory to high-dose methotrexate-based chemotherapy. small live christmas tree decorated

High-dose chemotherapy with thiotepa, busulfan, and ... - PubMed

WebHigh-dose therapy (HDTx) with autologous stem cell rescue has been widely applied in very-poor-risk pediatric solid tumors. Promising data have become available with the use … Web11 de abr. de 2003 · High-dose thiotepa, busulfan, cyclophosphamide and ASCT without whole-brain radiotherapy for poor prognosis primary CNS lymphoma. T Cheng 1,2, P … Web19 de abr. de 2004 · Children with high-risk and recurrent brain tumors currently have a poor prognosis. 1-5 To increase brain distribution of antitumor drugs that do not cross the blood-brain barrier at conventional dosages and to achieve higher concentrations within the tumor, high-dose chemotherapy (HDCT) followed by autologous hemopoietic stem cell … small live crickets

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Thiotepa-based high-dose therapy for autologous stem cell ...

Web1 de dez. de 2003 · Lazarus HM, Reed MD, Spitzer TR et al. High-dose i.v. thiotepa and cryopreserved autologous bone marrow transplantation for therapy of refractory cancer. Cancer Treat Rep 1987; 71: 689–695. WebHigh-dose thioTEPA is used frequently in myeloablative regimens for marrow transplantation, but the need for dose adjustments in obese patients has not been … small live edge wood ideasWebThe usual melphalan dose is 200 mg/m 2, although a ‘risk-adapted’ approach, with dose reduction to 140 mg/m 2 used in higher-risk patients in order to reduce transplant-related toxicity. r Criteria for defining ‘high-risk’ patients are; age >60, increased creatinine level, performance status (PS) 2 or compensated cardiac failure. sonik xp4 head torch

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High dose thiotepa

Thiotepa-based high-dose therapy for autologous stem cell ...

Web3 de nov. de 2024 · Thiotepa, a myeloablative, high-dose chemotherapeutic (HDT) treatment administered prior to autologous hematopoietic stem cell transplantation … WebThiotepa has been used recently at high doses in combination chemotherapy with cyclophosphamide in patients with refractory malignancies treated with autologous bone transplantation (Henner et …

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Web30 de jun. de 2024 · The pharmacokinetics of high dose thiotepa in children between 2 and 12 years of age do not appear to vary from those reported in children receiving 75 mg/m 2 or adults receiving similar doses. Renal impairment. The effects of renal impairment on thiotepa elimination have not been assessed. WebRelationship between size and thiazole orange ﬂuorescence of platelets in patients undergoing high-dose chemotherapy C. L. BALDUINI,1 P. N ORIS,1 P. S PEDINI,1 S. BELLETTI,1 A. ZAMBELLI2 AND G. A. DA PRADA2 1Institute of Internal Medicine and Medical Oncology, IRCCS Policlinico San Matteo, Pavia, and 2Division of Medical …

Web21 de set. de 2016 · Stewart DA, Forsyth P, Chaudhry A, et al: High dose thiotepa, busulfan, cyclophosphamide (TBC) and autologous hematopoietic stem cell transplantation (ASCT) without whole brain radiotherapy (WBRT) for primary central nervous system lymphoma (PCNSL). Blood (ASH Annual Meeting Abstracts) 104:: 4315, 2004, (abstr … Web11 de abr. de 2003 · High-dose thiotepa, busulfan, cyclophosphamide and ASCT without whole-brain radiotherapy for poor prognosis primary CNS lymphoma. T Cheng 1,2, P Forsyth 2,3, A Chaudhry 1,2, D Morris 1,2,

Web15 de set. de 2000 · High-dose thiotepa, used as a single agent or combined with other cytotoxics and supported by hematopoietic stem cell transplantation (HSCT), has been … Web15 de ago. de 2024 · High-dose chemotherapy with thiotepa, busulfan, and cyclophosphamide and autologous stem cell transplantation for patients with …

Web3 de abr. de 2024 · It is interesting to note that 9 patients were treated as part of a phase 2 trial of high-dose thiotepa, busulfan, and cyclophosphamide and high-dose rituximab with autologous stem cell transplantation for patients with CNS involvement by NHL or PCNSL. 10. Stem Cell Mobilization and Collection

WebBackground: Autologous stem cell transplantation (ASCT) generally provides good results in Hodgkin's lymphoma (HL). We studied a high-dose chemotherapy regimen based on … sonik whistleWeb13 de fev. de 2024 · Background: Serious neurological adverse events (NAE) have occurred during treatment with high-dose thiotepa regimens of children with high-risk solid … sonik sksc commercial waggler rod reviewWeb9 de set. de 2014 · Therefore, high-dose rituximab was combined with TBC for ASCT in patients with CNS NHL. METHODS. A single-arm phase 2 trial using high-dose … sonik xtractor spodWebThiotepa is a chemotherapy medicine used in combination with other drugs for the treatment of certain types of cancer in children. It is also used before bone marrow transplantation or high dose therapy with stem cell rescue to help treat certain types of cancer and metabolic conditions. sonik sksc commercial waggler rodWebSince, IOV of both thioTEPA and TEPA was equal to or smaller than IIV, therapeutic drug monitoring based on data of previous courses may be meaningful using this population model. AIMS To study the population pharmacokinetics of thioTEPA and its main metabolite TEPA in patients receiving high-dose chemotherapy consisting of thioTEPA (80-120 mg … sonik fly fishing rodsWeb15 de set. de 2024 · Disclosed are methods of treating cancer with a tri-agent therapy. The methods include a cancer treatment regimen with two or three different antineoplastic medications, including tamoxifen, gefitinib, and vinorelbine (TGV). The cancer treatment regimen can include sequential and/or concurrent administration of tamoxifen, gefitinib, … small live christmas trees walmartWeb20 de nov. de 2000 · The choice of the busulfan-thiotepa combination was based on pharmacologic evidence that both drugs readily cross the blood-brain barrier. In a study of plasma and CSF profiles among children who were treated with high dose busulfan, 37 the CSF to plasma ratio was 0.95 (range, 0.5–1.4). small live christmas tree in pot