Nephrin是什么蛋白
Web目的探讨小檗碱对高糖诱导肾小球足细胞损伤的保护作用及其机制。 方法体外培养小鼠肾小球足细胞，分为正常对照组、高糖模型组、不同浓度小檗碱组(30、60、90 μmol·L -1 )，分别处理足细胞。MTT法检测小檗碱对高糖诱导足细胞增殖能力的影响；Annexin V-FITC/PI双染实验观察小檗碱对高糖 ... WebFeb 17, 2024 · Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes. We previously reported ...
Nephrin是什么蛋白
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WebNov 12, 2016 · In a normal condition, the slit diaphragm complexes, including CD2AP, nephrin, and podocin, are stabilized. The expression of CIN85 is low and SUMOylated. In a diabetic condition, the expression of CD2AP is decreased. CIN85 is upregulated and released from SUMO. CIN85 can bind to both nephrin and podocin and induce … http://goysw.cnreagent.com/product_72968.html
http://zhongyibaodian.com/zs/57018.html Web1: 孙志强;白细胞介素-18和Nephrin在糖尿病肾病大鼠的表达及替米沙坦干预的研究[D];河南大学;2010年 2: 李素霞;通络保肾复方对肾小球足细胞表达nephrin影响的实验研究[D];北 …
Web【摘要】：目的:检测膜性肾病(MN)患者肾活检组织中nephrin、podocin的表达和分布,分析MN蛋白尿与nephrin和podocin表达改变的关系,探讨肾小球足细胞裂孔隔膜蛋白nephrin … WebNephrin是定位于足细胞裂隙膜的重要结构蛋白和信号转导分子，其磷酸化改变在调节足细胞存活及骨架蛋白重组中起重要作用，但nephrin磷酸化调控机制仍不清楚。Fyn激酶是磷 …
Webnephrin Antibody (G-8) is an IgG 2a κ mouse monoclonal nephrin antibody (also designated NPHS1 antibody, or adhesion molecule nephrin antibody)suitable for the …
WebNephrin is a transmembrane protein expressed entirely in glomerular podocytes [1]. Podocytes are large, terminally differentiated cells which create the visceral epithelial … petco west chester paNephrin is a protein necessary for the proper functioning of the renal filtration barrier. The renal filtration barrier consists of fenestrated endothelial cells, the glomerular basement membrane, and the podocytes of epithelial cells. Nephrin is a transmembrane protein that is a structural component of the slit … See more Nephrin has been shown to interact with: • CASK, • CD2AP, • CDH3 and • CTNND1, • FYN, See more • Podocyte See more • nephrin at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more • Tryggvason K (2002). "Nephrin: role in normal kidney and in disease". Adv. Nephrol. Necker Hosp. 31: 221–34. PMID 11692461 See more petco western ave allstonWebJun 20, 2024 · Nephrin (Nphs1) is an adhesion protein that is expressed at the podocyte intercellular junction in the glomerulus. Nphs1 mutations in humans or deletion in animal genetic models results in a developmental failure of foot process formation. A number of studies have shown decrease in expression of nephrin in various proteinuric kidney … petco west chesterWebAbstract. Background: Epithelial-to-mesenchymal transition (EMT) is a potential pathway leading to podocyte depletion and proteinuria in diabetic kidney disease (DKD).Here, we investigated the protective effects of Emodin (EMO) on high glucose (HG) induced-podocyte EMT in-vitro and in-vivo.Methods: Conditionally immortalized mouse podocytes were … star citizen jumptown scheduleWebThe antibody reacts specifically with nephrin, first described as a kidney podocyte marker protein (MW 135,000 calculated from aa sequence data; apparent Mr 185,000 after SDS-PAGE). Nephrin is a transmembrane cell adhesion molecule located at the slit di… petco western groomingWebnephrin 是免疫球蛋白是什么意思 petco west des moines iowaWebFeb 5, 2016 · Nephrin is expressed at the basolateral aspect of podocytes and is an important signaling protein at the glomerular slit diaphragm. In vitro studies have demonstrated that Nephrin phosphorylation-dependent signaling is able to assemble a protein complex that is able to polymerize actin. However, proximal signaling events that … petco westfield mall